Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus
Abstract Oncolytic adenoviruses (OAds), most of which are based on species C human adenovirus serotype 5 (Ad5) (OAd5), have recently received much attention as potential anticancer agents.High seroprevalence of anti-Ad5 neutralizing antibodies is a major hurdle for Ad5-based gene therapy.However, the impacts of anti-Ad5 neutralizing antibodies on O