EFFECTS OF PRE-EXISTING ANTI-ADENOVIRUS ANTIBODIES ON TRANSGENE EXPRESSION LEVELS AND THERAPEUTIC EFFICACIES OF ARMING ONCOLYTIC ADENOVIRUS

Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus

Abstract Oncolytic adenoviruses (OAds), most of which are based on species C human adenovirus serotype 5 (Ad5) (OAd5), have recently received much attention as potential anticancer agents.High seroprevalence of anti-Ad5 neutralizing antibodies is a major hurdle for Ad5-based gene therapy.However, the impacts of anti-Ad5 neutralizing antibodies on O

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